McCoull, William published the artcileIdentification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes, Product Details of C10H16N4, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(12), 3873-3878, database is CAplus and MEDLINE.
A novel series of DGAT-1 inhibitors was discovered from an oxadiazole amide high throughput screening (HTS) hit. Optimization of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid containing clin. candidate 53 (AZD3988, I), which demonstrated excellent DGAT-1 potency (0.6 nM), good pharmacokinetics and pre-clin. in vivo efficacy that could be rationalised through a PK/PD relationship.
Bioorganic & Medicinal Chemistry Letters published new progress about 55403-35-5. 55403-35-5 belongs to piperazines, auxiliary class Pyridine,Piperazine,Amine, name is 6-(4-Methylpiperazin-1-yl)pyridin-3-amine, and the molecular formula is C10H16N4, Product Details of C10H16N4.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics