Property space mapping of Pseudomonas aeruginosa permeability to small molecules was written by Leus, Inga V.;Weeks, Jon W.;Bonifay, Vincent;Shen, Yue;Yang, Liang;Cooper, Connor J.;Nash, Dinesh;Duerfeldt, Adam S.;Smith, Jeremy C.;Parks, Jerry M.;Rybenkov, Valentin V.;Zgurskaya, Helen I.. And the article was included in Scientific Reports in 2022.Category: piperazines The following contents are mentioned in the article:
Two membrane cell envelopes act as selective permeability barriers in Gram-neg. bacteria, protecting cells against antibiotics and other small mols. Significant efforts are being directed toward understanding how small mols. permeate these barriers. In this study, we developed an approach to analyze the permeation of compounds into Gram-neg. bacteria and applied it to Pseudomonas aeruginosa, an important human pathogen notorious for resistance to multiple antibiotics. The approach uses mass spectrometric measurements of accumulation of a library of structurally diverse compounds in four isogenic strains of P. aeruginosa with varied permeability barriers. We further developed a machine learning algorithm that generates a deterministic classification model with minimal synonymity between the descriptors. This model predicted good permeators into P. aeruginosa with an accuracy of 89% and precision above 58%. The good permeators are broadly distributed in the property space and can be mapped to six distinct regions representing diverse chem. scaffolds. We posit that this approach can be used for more detailed mapping of the property space and for rational design of compounds with high Gram-neg. permeability. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Category: piperazines).
1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics