A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea was written by Pan, Jiezhou;Gong, Guidong;Wang, Qin;Shang, Jiaojiao;He, Yunxiang;Catania, Chelsea;Dan, Birnbaum;Li, Yifei;Jia, Zhijun;Zhang, Yaoyao;Joshi, Neel S.;Guo, Junling. And the article was included in Nature Communications in 2022.Related Products of 70458-96-7 The following contents are mentioned in the article:
The gut microbiota represents a large community of microorganisms that play an important role in immune regulation and maintenance of homeostasis. Living bacteria receive increasing interest as potential therapeutics for gut disorders, because they inhibit the colonization of pathogens and pos. regulate the composition of bacteria in gut. However, these treatments are often accompanied by antibiotic administration targeting pathogens. In these cases, the efficacy of therapeutic bacteria is compromised by their susceptibility to antibiotics. Here, we demonstrate that a single-cell coating composed of tannic acids and ferric ions, referred to as nanoarmor, can protect bacteria from the action of antibiotics. The nanoarmor protects both Gram-pos. and Gram-neg. bacteria against six clin. relevant antibiotics. The multiple interactions between the nanoarmor and antibiotic mols. allow the antibiotics to be effectively absorbed onto the nanoarmor. Armored probiotics have shown the ability to colonize inside the gastrointestinal tracts of levofloxacin-treated rats, which significantly reduced antibiotic-associated diarrhea (AAD) resulting from the levofloxacin-treatment and improved some of the pre-inflammatory symptoms caused by AAD. This nanoarmor strategy represents a robust platform to enhance the potency of therapeutic bacteria in the gastrointestinal tracts of patients receiving antibiotics and to avoid the neg. effects of antibiotics in the gastrointestinal tract. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Related Products of 70458-96-7).
1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Related Products of 70458-96-7
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics