Heinz, Christoph published the artcileNi-Catalyzed Carbon-Carbon Bond-Forming Reductive Amination, Formula: C13H18N2, the publication is Journal of the American Chemical Society (2018), 140(6), 2292-2300, database is CAplus and MEDLINE.
This report describes a three-component, Ni-catalyzed reductive coupling that enables the convergent synthesis of tertiary benzhydryl amines (e.g. I), which are challenging to access by traditional reductive amination methodologies. The reaction makes use of iminium ions generated in situ from the condensation of secondary N-trimethylsilyl amines with benzaldehydes, and these species undergo reaction with several distinct classes of organic electrophiles. The synthetic value of this process is demonstrated by a single-step synthesis of antimigraine drug flunarizine (Sibelium) and high yielding derivatization of paroxetine (Paxil) and metoprolol (Lopressor). Mechanistic investigations support a sequential oxidative addition mechanism rather than a pathway proceeding via ¦Á-amino radical formation. Accordingly, application of catalytic conditions to an intramol. reductive coupling is demonstrated for the synthesis of endo- and exocyclic benzhydryl amines.
Journal of the American Chemical Society published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Formula: C13H18N2.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics