Dyatkin, Alexey B.’s team published research in Tetrahedron Letters in 39 | CAS: 87179-40-6

Dyatkin, Alexey B. published the artcileThe solid phase synthesis of complex propargylamines using the combination of Sonogashira and Mannich reactions, Quality Control of 87179-40-6, the publication is Tetrahedron Letters (1998), 39(22), 3647-3650, database is CAplus.

The Sonogashira alkynylation reaction of resin-bound iodobenzoic acids, e.g. 4-IC₆H₄CO₂H, with Me₃SiCCH followed by TBAF desilylation provided polymer-supported aryl acetylenes, e.g. 4-(HCC)C₆H₄CO₂H. Treatment of the latter with aldehydes, e.g. R¹CHO [R¹ = 4-MeC₆H₄, 3-FC₆H₄, 3-(PhO)C₆H₄, 1-naphthyl, 4-PhC₆H₄] and secondary amines, e.g. piperazines I (R² = trans-PhCH:CHCH₂, 2,3-Me₂C₆H₃, 2-FC₆H₄, cyclohexyl, Ph) in dioxane in the presence of CuCl catalyst results in the generation of resin-bound propargylamines . The final products, e.g. II, were cleaved from the resin and obtained in excellent yields and purity. This method provides a straightforward synthesis of diverse libraries of complex propargylamines.

Tetrahedron Letters published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Quality Control of 87179-40-6.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics