Choi, Min Jeong published the artcileSynthesis and Biological Evaluation of Aryloxazole Derivatives as Antimitotic and Vascular-Disrupting Agents for Cancer Therapy, Category: piperazines, the publication is Journal of Medicinal Chemistry (2013), 56(22), 9008-9018, database is CAplus and MEDLINE.
Aryloxazolecarbonyl, arylthiazolecarbonyl, and arylisoxazolecarbonyl arylpiperazines and aryloxazolecarbonyl arylpiperidines such as fluorophenyloxazolecarbonyl arylpiperazines I (R = Cl, MeO) were prepared as antimitotic, antiangiogenic, and antitumor agents. Selected aryloxazolecarbonyl arylpiperazines such as I (R = Cl) inhibited angiogenesis, showed antitumor activity, and were stable to human microsomes. I (R = Cl, MeO) were tested against mice with human tumor cell (HCT-116) xenografts; I reduced the tumor size in vivo at a dose of 100 mg/kg but was toxic at a dose of 200 mg/kg.
Journal of Medicinal Chemistry published new progress about 178928-58-0. 178928-58-0 belongs to piperazines, auxiliary class Piperazine,Nitrile,Benzene, name is 1-(3-Cyanophenyl)piperazine, and the molecular formula is C11H13N3, Category: piperazines.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics