Molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for specific recognition and determination of chloramphenicol in milk was written by Geng, Lingjun;Huang, Jingcheng;Zhai, Hongguo;Shen, Zheng;Han, Jie;Yu, Yanyang;Fang, Honggang;Li, Falan;Sun, Xia;Guo, Yemin. And the article was included in Microchemical Journal in 2022.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:
A molecularly imprinted electrochem. sensor of chloramphenicol (CAP) with high sensitivity and good selectivity is introduced in this paper. Glassy carbon electrode (GCE) was modified by chitosan-multiwalled carbon nanotubes (CS-MWCNTs), the CS could improve the dispersion of MWCNTS, and the MWCNTS could significantly improve the current response of the sensor, thus improving the sensitivity. CAP was used as a template mol. and o-phenylenediamine (o-PD) was used as a functional monomer, resp. Molecularly imprinted polymers (MIPs) were prepared on the surface of a GCE modified with CS-MWCNTs by electro-polymerization The MIPs provided specific recognition sites for the detection of chloramphenicol. The exptl. parameters such as polymerization cycle, concentration ratio of template mol. to functional monomer, supporting electrolyte pH and incubation time were optimized. Under optimized exptl. conditions, the sensor has a linear range of 0.1-1000 ng/mL and the limit of detection (LOD) of 3.3 x 10-2 ng/mL (S/N = 3). The sensor had high selectivity, good stability and reproducibility for the detection of CAP, and it has been successfully used for the determination of CAP in real spiked milk samples. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).
1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics