Tomishima, Masaki published the artcileNovel echinocandin antifungals. Optimization of the side chain of the natural product FR901379. Discovery of micafungin, Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(9), 2886-2890, database is CAplus and MEDLINE.
Further optimization of the potent antifungal activity of side chain analogs of the natural product FR901379 led to the discovery of compound (I) with an excellent, well-balanced profile. Potent compounds with reduced hemolytic potential were designed based upon a disruption of the linearity of the terphenyl lipophilic side chain. The optimized compound I (FK463, micafungin) displayed the best balance and was selected as the clin. candidate.
Bioorganic & Medicinal Chemistry Letters published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C7H9BO3S, Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics