Li, Xiang published the artcileSynthesis, Biological Evaluation, and Molecular Docking Studies of Xanthone Sulfonamides as ACAT Inhibitors, Safety of 1-(3-Cyanophenyl)piperazine, the publication is Chemical Biology & Drug Design (2015), 85(3), 394-403, database is CAplus and MEDLINE.
Three series of xanthone sulfonamides were synthesized, and their inhibitory activities against acyl-Co-A: cholesterol acyltransferase (ACAT) were evaluated. Results showed that most of the title compounds exhibited strong inhibitory activity against ACAT, and several compounds were proved to be more active than the pos. control Sandoz 58-035. Computational docking experiments indicated that the interaction between inhibitors and ACAT contained the H-bond interaction, the hydrophobic interaction, and the narrow hydrophobic cleft.
Chemical Biology & Drug Design published new progress about 178928-58-0. 178928-58-0 belongs to piperazines, auxiliary class Piperazine,Nitrile,Benzene, name is 1-(3-Cyanophenyl)piperazine, and the molecular formula is C11H13N3, Safety of 1-(3-Cyanophenyl)piperazine.
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https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics