Xu, Feng published the artcileSynthesis, antitumor evaluation and molecular docking studies of [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine derivatives, COA of Formula: C8H16N2O, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(13), 3042-3047, database is CAplus and MEDLINE.
A series of [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine derivatives were synthesized and evaluated for their antitumor activities. These compounds exhibited potent antiproliferative activities against MCF-7, Bewo and HL-60 cells and c-Met kinase inhibitory activities. Three compounds were highly effective against MCF-7, Bewo and HL-60 cells with IC50 values in 1.09-2.24 μM. Mol. docking was further performed to study the inhibitor-c-Met kinase interactions, and compound 4-([1,2,4]Triazolo[4,3-b][1,2,4,5]tetrazin-3-yl)morpholine was potently bound to the c-Met kinase with three hydrogen bonds. The further research on acute toxicity and in vivo antitumor activity of compound 4-([1,2,4]Triazolo[4,3-b][1,2,4,5]tetrazin-3-yl)morpholine to ICR (Institute of Cancer Research) mice were carried out, and found 4-([1,2,4]Triazolo[4,3-b][1,2,4,5]tetrazin-3-yl)morpholine with a certain toxicity but good efficacy in vivo. Based on the preliminary results, compound 4-([1,2,4]Triazolo[4,3-b][1,2,4,5]tetrazin-3-yl)morpholine with potent c-Met kinase inhibitory activity may be a potential anticancer agent.
Bioorganic & Medicinal Chemistry Letters published new progress about 71260-16-7. 71260-16-7 belongs to piperazines, auxiliary class Piperazine, name is 2-Methyl-1-(piperazin-1-yl)propan-1-one, and the molecular formula is C25H23NO4, COA of Formula: C8H16N2O.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics