Synthesis, biological evaluation, and molecular docking study of thiophene-, piperazine-, and thiazolidinone-based hybrids as potential antimicrobial agents was written by Desai, Nisheeth C.;Rupala, Yogesh M.;Khasiya, Ashvinkumar G.;Shah, Keyur N.;Pandit, Unnat P.;Khedkar, Vijay M.. And the article was included in Journal of Heterocyclic Chemistry in 2022.Reference of 21867-64-1 This article mentions the following:
Antibiotic resistance in bacteria exacerbates the issue of antimicrobial resistance. Bacteria that cause common or serious infections have evolved resistance to every new antibiotic that has been introduced into the market, to varying degrees, over several decades. Faced with this reality, one of societys most urgent needs is for new antimicrobial drugs with novel mechanisms of action. With this objective, we describe here the development of a novel set of compounds including piperazine- and thiophene-based thiazolidinones (5a-i) and thiophene-thiazolidinones (6a-i). Compounds (5a-i) and (6a-i) were developed, synthesized, and tested for their antimicrobial activity, and their structures were elucidated with the help of various anal. techniques. Compounds 5a and 5d showed excellent antibacterial efficacy against Pseudomonas aeruginosa, with MICs of 50 μg/mL, whereas compounds 6c and 6e showed similar potency against Staphylococcus aureus and Escherichia coli, resp. The antifungal efficacy of compounds 5e and 6i against Candida albicans was outstanding (MIC = 50 μg/mL). The only compound that had excellent antifungal efficacy against Aspergillus niger was compound 5e (MIC = 50 μg/mL). The chemico-in silico-biol. approach could provide valuable insights into the potential of this novel hybridized scaffold for the development of promising antimicrobial agents. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Reference of 21867-64-1).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Reference of 21867-64-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics