Design and synthesis of an anticancer diarylurea derivative with multiple-kinase inhibitory effect was written by El-Gamal, Mohammed I.;Oh, Chang-Hyun. And the article was included in Bulletin of the Korean Chemical Society in 2012.Name: 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline This article mentions the following:
A pyrrolo[3,2-c]pyridine derivative [N-[1-[4-[[[[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide (I)] was designed and the synthesis of the target compound was achieved using N-[1-(4-aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide and 4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzenamine as key reactants. I was evaluated in a five-dose mode to determine its IC50, TGI, and LC50 values over the 60 cell lines. I displayed high potency and good efficacy and was accordingly tested at a single dose concentration of 10 μM over a panel of 40 kinases. At this concentration, it completely inhibited the enzymic activities of a number of oncogenic kinases, including ABL [kinase (phosphorylating) gene abl protein], ALK [kinase (phosphorylating) gene ALK protein], c-RAF [kinase (phosphorylating) gene raf-1 protein], FLT3 [kinase (phosphorylating) gene FLT3 receptor], KDR [kinase (phosphorylating) gene flk-1 protein] and TrkB [kinase (phosphorylating) gene trkB neurotropic factor receptor]. I was subsequently tested over these 6 kinases in 10-dose testing mode in order to determine its IC50 values. In the experiment, the researchers used many compounds, for example, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6Name: 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline).
4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Name: 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics