Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids was written by Hayakawa, Isao;Hiramitsu, Tokiyuki;Tanaka, Yoshiaki. And the article was included in Chemical & Pharmaceutical Bulletin in 1984.Computed Properties of C7H16N2 This article mentions the following:
Title compounds I [R = H, Me; R1 = F, Cl; R2 = (substituted) piperazino, piperidino, diazepino, pyrrolidino, etc.] (44 compounds) were prepared from nitrobenzenes II (R1, R3, R4 = F, F, F; Cl, F, Cl; F, Cl, F) via benzoxazines III. I (R = Me, R1 = F, R2 = 4-methyl-1-piperazinyl) (DL-8280) showed potent antibacterial activity against Gram-pos. and -neg. pathogens, including Pseudomonas aeruginosa, and its metabolic disposition was shown in sep. experiments to be favorable. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Computed Properties of C7H16N2).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Computed Properties of C7H16N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics