Synthesis and optimization of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors was written by Ryu, Je Ho;Kim, Shinae;Lee, Jung A.;Han, Hye Young;Son, Hyun Joo;Lee, Hyun Jung;Kim, Yong Hyuk;Kim, Jae-Sun;Park, Hyeung-geun. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Application In Synthesis of 6-(Piperazin-1-yl)nicotinonitrile This article mentions the following:
The synthesis and structure-activity relationship of a series of 6-substituted picolinamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1 are described. The optimization of the left-hand side of lead compound I resulted in the discovery of the highly potent, selective, and orally available inhibitor II, which demonstrated an excellent activity in a mouse ex vivo pharmacodynamic model. Moreover, II reduced the blood glucose and improved the lipid profiles in ob/ob mice after oral administration. In the experiment, the researchers used many compounds, for example, 6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0Application In Synthesis of 6-(Piperazin-1-yl)nicotinonitrile).
6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application In Synthesis of 6-(Piperazin-1-yl)nicotinonitrile
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics