Synthesis of N-(3-amino-2-hydroxy propyl)-N-sulfonylanilines derivatives. Potential antianginal activities was written by Goldenberg, Charles;Van Meerbeeck, Clement;Wandestrick, Raymond;Descamps, Marcel;Tornay, Chantal;Dirks, Michel;Colot, Michel;De Claviere, Michel. And the article was included in European Journal of Medicinal Chemistry in 1980.Category: piperazines This article mentions the following:
The title compounds I [R = 2-allyloxy, 4-AcNH, 4-H2NCOCH2, R1 = H; R = 2-Cl, R1 = 6-Cl; R = 3-Cl, R1 = 4-Cl; R2 = Me, 4-MeC6H4, 4-MeOC6H4, Ph; R3 = H, R4 = CHMe2, CMe3, CH2CH2OPh, (CH2)3Ph; NR3R4 = pyrrolidino, morpholino, 4-substituted piperazino] were prepared by sulfonylating RR1C6H3NH2, treating RR1C6H3NHSO2R2 with epichlorohydrin, and aminolysis. I have both α- and β-sympatholytic activity. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Category: piperazines).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics