Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture was written by Conte, Immacolata;Giuliano, Claudio;Ercolani, Caterina;Narjes, Frank;Koch, Uwe;Rowley, Michael;Altamura, Sergio;De Francesco, Raffaele;Neddermann, Petra;Migliaccio, Giovanni;Stansfield, Ian. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Computed Properties of C16H22N2O4 This article mentions the following:
The RNA replication machinery of HCV is a multi-subunit membrane-associated complex. NS5A has emerged as an active component of HCV replicase, possibly involved in regulation of viral replication and resistance to the antiviral effect of interferon. Substituted piperazinyl-N-(aryl)benzamides were prepared as potent inhibitors of HCV replication exerted via modulation of the dimerization of NS5A. In the experiment, the researchers used many compounds, for example, 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid (cas: 162046-66-4Computed Properties of C16H22N2O4).
4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid (cas: 162046-66-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Computed Properties of C16H22N2O4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics