Coteron, Jose M. et al. published their research in Journal of Medicinal Chemistry in 2010 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Reference of 21867-64-1

Falcipain Inhibitors: Optimization Studies of the 2-Pyrimidinecarbonitrile Lead Series was written by Coteron, Jose M.;Catterick, David;Castro, Julia;Chaparro, Maria J.;Diaz, Beatriz;Fernandez, Esther;Ferrer, Santiago;Gamo, Francisco J.;Gordo, Mariola;Gut, Jiri;de las Heras, Laura;Legac, Jennifer;Marco, Maria;Miguel, Juan;Munoz, Vicente;Porras, Esther;de la Rosa, Juan C.;Ruiz, Jose R.;Sandoval, Elena;Ventosa, Pilar;Rosenthal, Philip J.;Fiandor, Jose M.. And the article was included in Journal of Medicinal Chemistry in 2010.Reference of 21867-64-1 This article mentions the following:

Falcipain-2 and falcipain-3 are papain-family cysteine proteases of the malaria parasite Plasmodium falciparum that are responsible for host Hb hydrolysis to provide amino acids for parasite protein synthesis. Different heteroarylnitrile derivatives were studied as potential falcipain inhibitors and therefore potential antiparasitic lead compounds, with the 5-substituted-2-cyanopyrimidine chem. class emerging as the most potent and promising lead series. Through a sequential lead optimization process considering the different positions present in the initial scaffold, nanomolar and subnanomolar inhibitors at falcipains 2 and 3 were identified, with activity against cultured parasites in the micromolar range. Introduction of protonable amines within lead mols. led to marked improvements of up to 1000 times in activity against cultured parasites without noteworthy alterations in other SAR tendencies. Optimized compounds presented enzymic activities in the picomolar to low nanomolar range and antiparasitic activities in the low nanomolar range. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Reference of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Reference of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics