Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) was written by Pescatore, Giovanna;Branca, Danila;Fiore, Fabrizio;Kinzel, Olaf;Bufi, Laura Llauger;Muraglia, Ester;Orvieto, Federica;Rowley, Michael;Toniatti, Carlo;Torrisi, Caterina;Jones, Philip. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Formula: C10H12N4 This article mentions the following:
The discovery of a novel series of pyrrolo[1,2-a]pyrazin-1(2H)-one PARP inhibitors is described. Optimization led to compounds that display excellent PARP-1 enzyme potency and inhibit the proliferation of BRCA deficient cells in the low double-digit nanomolar range showing excellent selectivity over BRCA proficient cancer cells. In the experiment, the researchers used many compounds, for example, 6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0Formula: C10H12N4).
6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Formula: C10H12N4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics