Studies on the compounds related to azulene. I. Synthesis and antiallergic activity of guaiazulenylglyoxylamides, guaiazulenylglyoxylic acid esters and acylaminoguaiazulenes was written by Hamajima, Ryo;Iwano, Katsuyuki;Okuda, Hirohisa. And the article was included in Yakugaku Zasshi in 1978.Name: 1-Propylpiperazine This article mentions the following:
New guaiazulenylglyoxylamides, guaiazulenglyoxylic acid esters, guaiazulenylglyoxypiperazines, and acylaminoguaiazulenes were prepared, and their antiallergic activities were evaluated by passive cutaneous anaphylaxis (PCA) test in the rat. Guaiazulenylglyoxalyl chloride I (R = Cl) derived from guaiazulene and oxalyl chloride was converted into glyoxylamides, glyoxylic acid esters, and glyoxylpiperazines with appropriate amines, alcs., and piperazines. Acylaminoguaiazulenes were prepared from 3-aminoguaiazulene with the corresponding acid anhydride or acid chloride. Many of guaiazulenylglyoxylpiperazines, especially I (R = 4-R1-piperazin-1-yl; R1 = H, Me, Et, CH2CO2H, PhCH2) showed a high antiallergic activity by oral administration, but none of the other types of compounds showed a significant activity. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Name: 1-Propylpiperazine).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Name: 1-Propylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics