Karpov, Alexei S. et al. published their research in ACS Medicinal Chemistry Letters in 2018 | CAS: 162046-66-4

4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid (cas: 162046-66-4) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Recommanded Product: 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid

Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates was written by Karpov, Alexei S.;Abrams, Tinya;Clark, Suzanna;Raikar, Ankita;D’Alessio, Joseph A.;Dillon, Michael P.;Gesner, Thomas G.;Jones, Darryl;Lacaud, Marion;Mallet, William;Martyniuk, Piotr;Meredith, Erik;Mohseni, Morvarid;Nieto-Oberhuber, Cristina M.;Palacios, Daniel;Perruccio, Francesca;Piizzi, Grazia;Zurini, Mauro;Bialucha, Carl Uli. And the article was included in ACS Medicinal Chemistry Letters in 2018.Recommanded Product: 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid This article mentions the following:

Antibody-drug conjugates (ADCs) are a novel modality that allows targeted delivery of potent therapeutic agents to the desired site. Herein we report our discovery of NAMPT inhibitors as a novel nonantimitotic payload for ADCs. The resulting anti-c-Kit conjugates (ADC-3 and ADC-4) demonstrated in vivo efficacy in the c-Kit pos. gastrointestinal stromal tumor GIST-T1 xenograft model in a target-dependent manner. In the experiment, the researchers used many compounds, for example, 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid (cas: 162046-66-4Recommanded Product: 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid).

4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid (cas: 162046-66-4) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Recommanded Product: 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics