Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant was written by Shieh, Wen-Chung;McKenna, Joe;Sclafani, Joseph A.;Xue, Song;Girgis, Michael;Vivelo, James;Radetich, Branko;Prasad, Kapa. And the article was included in Organic Process Research & Development in 2008.Product Details of 630125-91-6 This article mentions the following:
We have designed and developed an alternative synthesis for the manufacturing of a triad of Flt3 kinase inhibitors (AST487, ATH686, and AUZ454) to support clin. assessments of patients with Flt3-dependent tumor diseases. The new synthesis is convergent, environmentally friendly, practical, and safe and requires no chromatog. purification In the experiment, the researchers used many compounds, for example, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6Product Details of 630125-91-6).
4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Product Details of 630125-91-6
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics