Glutathione. X. Human erythrocyte membrane diffusion coefficients for diazene derivatives of the DIP [diazenedicarboxylic acid bis(N’-methylpiperazide)] series via intracellular thiol oxidation was written by Kosower, Nechama S.;Kosower, Edward M.;Saltoun, Gilda;Lev, Lilly. And the article was included in Biochemical and Biophysical Research Communications in 1975.Application of 21867-64-1 This article mentions the following:
The thiol-oxidizing agent, DIP and its homologs with different N’-alkyl groups can be used to obtain membrane diffusion coefficients for human erythrocytes at 1°. From the initial rates of intracellular glutathione oxidation and the 2-octanol partition coefficients for the specific DIP homolog, diffusion coefficients of ∼1 × 10-8 cm2/sec were observed The method (irreversible loss of permeant through well-defined intracellular reaction) may be used to evaluate membrane properties and possibly for the study of substituent effects on drug entry into cells. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Application of 21867-64-1).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Application of 21867-64-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics