Synthesis and amination of 2,4-dichloro-5-fluoropyrimidine was written by Kovalenko, A. L.;Krutikov, V. I.;Zolotukhina, M. M.;Alekseeva, L. E.. And the article was included in Zhurnal Obshchei Khimii in 1992.Formula: C7H16N2 This article mentions the following:
Chlorination of 5-fluorouracil by PCl5 in the absence of solvent gave 92% dichlorofluoropyrimidine I which underwent amination by primary, secondary, and heterocyclic amines in aqueous solution to give 42-100% amines II [R = NH2, H2NC(:NH)NH, CH2:CHCH2NH, piperidino, 1-propylpiperazinyl, morpholino, imidazol-1-yl]. Amines II were fungicidal at 100 μg/mL against Candida, Cryptococcus, Aspergillus et al. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Formula: C7H16N2).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Formula: C7H16N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics