Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting αvβ3/αIIbβ3 dual antagonistic activity was written by Kubota, Dai;Ishikawa, Minoru;Yamamoto, Mikio;Murakami, Shoichi;Hachisu, Mitsugu;Katano, Kiyoaki;Ajito, Keiichi. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Electric Literature of C16H22N2O4 This article mentions the following:
In order to generate novel compounds with integrin αvβ3-antagonistic activity together with antiplatelet activity, tricyclic pharmacophore-based mols. were designed and synthesized. Although piperazine-containing compounds initially prepared were selective αIIbβ3 antagonists, replacement of piperazine with piperidine furnished a potent αvβ3/αIIbβ3 dual antagonist. Structure-activity relationship (SAR) studies provided clues for further development of tricyclic pharmacophore-based integrin antagonists. In the experiment, the researchers used many compounds, for example, 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid (cas: 162046-66-4Electric Literature of C16H22N2O4).
4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid (cas: 162046-66-4) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C16H22N2O4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics