Wang, Yuxia et al. published their research in Chemical Biology & Drug Design in 2017 | CAS: 373608-48-1

tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate (cas: 373608-48-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Related Products of 373608-48-1

Synthesis and evaluation of novel amonafide-polyamine conjugates as anticancer agents was written by Wang, Yuxia;Zhang, Jianying;Li, Meng;Li, Ming;Xie, Songqiang;Wang, Chaojie. And the article was included in Chemical Biology & Drug Design in 2017.Related Products of 373608-48-1 This article mentions the following:

Hydrochloride salts of aminoacetamido and ureido-substituted analogs of amonafide I [R = Bu, cyclohexyl, Me2NCH2CH2, H2N(CH2)3, H2N(CH2)4, 3-(4-Boc-1-piperazinyl)propyl, H2N(CH2)nNH(CH2)m, H2N(CH2)mNH(CH2)nNH(CH2)m; m, n = 1, 2; X = bond, CH2] were prepared as potential antitumor agents; their antitumor activity against various human cancer cell lines, the toxicities of selected compounds, and the in vivo antitumor activity and inhibition of cell migration and metastasis of I•5 HCl [R = H2N(CH2)2NH(CH2)2NH(CH2)2; X = CH2] (II) alone in concert with aspirin were determined Amonafide analogs with urea linkers were not active. Aspirin elevated the potency of II against tumor cells, wound healing, and the protein expression of cyclic D1 and MMP9; in vivo trials on three H22 tumor transplant models demonstrated that the combination of II and aspirin inhibited tumor growth and metastasis and extended lifespan while showing reduced side effects compared to amonafide. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate (cas: 373608-48-1Related Products of 373608-48-1).

tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate (cas: 373608-48-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Related Products of 373608-48-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics