Improvement on the synthetic process of N-aryl piperazines was written by Liu, Ning;Chen, Jin-chun. And the article was included in Guangzhou Huagong in 2014.HPLC of Formula: 182618-86-6 This article mentions the following:
By using N,N-bis(2-chloroethyl) amine hydrochloride and substituted aniline as initial material, Bu alc. as the solvent, refluxing in the absence of base to convert to corresponding N-aryl piperazines in high yield. The structure was confirmed by 1H-NMR. The product can crystallize directly from the system and the filtrate can be used several times so that the new synthetic method was applicable in the industrial scale production Compared to the reported method, the new process simplified the operation steps, reduced the difficulty of the product separation and improved the yield and purity of the product. In the experiment, the researchers used many compounds, for example, 1-Boc-4-(4-Nitrophenyl)piperazine (cas: 182618-86-6HPLC of Formula: 182618-86-6).
1-Boc-4-(4-Nitrophenyl)piperazine (cas: 182618-86-6) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.HPLC of Formula: 182618-86-6
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics