1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity was written by Miller-Moslin, Karen;Peukert, Stefan;Jain, Rishi K.;McEwan, Michael A.;Karki, Rajesh;Llamas, Luis;Yusuff, Naeem;He, Feng;Li, Yanhong;Sun, Yingchuan;Dai, Miao;Perez, Lawrence;Michael, Walter;Sheng, Tao;Lei, Huangshu;Zhang, Rui;Williams, Juliet;Bourret, Aaron;Ramamurthy, Arun;Yuan, Jing;Guo, Ribo;Matsumoto, Melissa;Vattay, Anthony;Maniara, Wieslawa;Amaral, Adam;Dorsch, Marion;Kelleher, Joseph F. III. And the article was included in Journal of Medicinal Chemistry in 2009.COA of Formula: C10H12N4 This article mentions the following:
Abnormal activation of the Hedgehog (Hh) signaling pathway has been linked to several types of human cancers, and the development of small-mol. inhibitors of this pathway represents a promising route toward novel anticancer therapeutics. A cell-based screen performed in our laboratories identified a new class of Hh pathway inhibitors, 1-amino-4-benzylphthalazines, e.g. I, that act via antagonism of the Smoothened receptor. A variety of analogs were synthesized and their structure-activity relationships determined This optimization resulted in the discovery of high affinity Smoothened antagonists, one of which was further profiled in vivo. This compound displayed a good pharmacokinetic profile and also afforded tumor regression in a genetic mouse model of medulloblastoma. In the experiment, the researchers used many compounds, for example, 6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0COA of Formula: C10H12N4).
6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).COA of Formula: C10H12N4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics