Synthesis of New 5-(1,4-Benzodioxan-2-yl)thieno[2,3-d]pyrimidine Derivatives was written by Vardanyan, S. O.;Aghekyan, A. A.;Avagyan, A. S.;Sargsyan, A. B.;Panosyan, H. A.;Harutyunyan, S. A.;Gasparyan, H. V.. And the article was included in Russian Journal of Organic Chemistry in 2022.Name: 1-Propylpiperazine This article mentions the following:
Cyclization of previously synthesized Et 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate with formamide gave 5-(1,4-benzodioxan-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one which was treated with phosphoryl chloride in pyridine to obtain the corresponding 4-chloro derivative The latter reacted with various primary and secondary amines to produce a series of new thieno[2,3-d]pyrimidines containing a pharmacophoric fragment at the 4-position. The reaction of 5-(1,4-benzodioxan-2-yl)-4-chlorothieno[2,3-d]pyrimidine with hydrazine hydrate afforded the corresponding 4-hydrazinyl derivative which was cyclized with formic acid to thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivative Antihypoxic properties of the synthesized compounds were studied. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Name: 1-Propylpiperazine).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Name: 1-Propylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics