Synthesis of piperazine derivatives. XII. Preparation of N1-substituted N4-(3-phenylpropyl)piperazines was written by Zikolova, S.. And the article was included in Trudove na Nauchnoizsledovatelskiya Khimikofarmatsevtichen Institut in 1978.Application In Synthesis of 1-Propylpiperazine This article mentions the following:
N-(3-Phenylpropyl)piperazine was alkylated with alkyl halides (e.g., EtI) in refluxing solvent containing Na2CO3 to give 26 title compounds [I; R = C1-C8 alkyl, allyl, crotyl, cycloalkyl, aralkyl, (aryloxy)alkyl, XCH2CH2; X = Et2N, piperidino, morpholino] in 65-98% yield, isolated as hydrochlorides and oxalates. I (R = Me) was also prepared from N-methylpiperazine and Pr(CH2)3Br (II) and I [R = Ph(CH2)3], from II and piperazine. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Application In Synthesis of 1-Propylpiperazine).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Application In Synthesis of 1-Propylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics