The use of solid-supported reagents for the multi-step synthesis of analytically pure α,β-unsaturated compounds in miniaturized flow reactors was written by Wiles, Charlotte;Watts, Paul;Haswell, Stephen J.. And the article was included in Lab on a Chip in 2007.Electric Literature of C7H16N2 This article mentions the following:
Micro reaction technol. offers a safe, controllable and information rich technique suitable for the long-term production of pharmaceutical agents and fine chems. To date however, few of the syntheses performed using this technol. have addressed the problems associated with product purification The incorporation of multiple supported reagents into EOF-based miniaturized flow reactors for the two-step synthesis of anal. pure compounds is reported. Using this approach, the successful synthesis of 20 α,β-unsaturated compounds in excellent yields (>99.1%) and purities (>99.9%) has been achieved, illustrating significant improvements compared to traditional batch techniques. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Electric Literature of C7H16N2).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Electric Literature of C7H16N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics