Producing of a novel condensed heterocycles and combinatorial libraries on the basis of 2-amino-5-bromopyridine-3-sulfochloride was written by Dorogov, M. V.;Solov’ev, M. Yu.;Kravchenko, D. V.;Blyumina, M. V.;Tkachenko, S. E.;Ivashchenko, A. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2005.COA of Formula: C7H16N2 This article mentions the following:
2-Amino-5-bromopyridine-3-sulfonyl chloride (I) was readily prepared by chlorosulfonylation of 2-amino-5-bromopyridine. Subsequent amination of I with primary or secondary amines or with amino acids, such as sarcosine or β-alanine, gave the libraries of the corresponding 2-amino-5-bromo-3-pyridinesulfonamides and 2-amino-5-bromo-3-pyridinesulfonylamino-substituted carboxylic acids, resp. The latter were further amidated with various primary and secondary amines to afford the libraries of pyridylsulfonylamino-functionalized carboxamides. On the other hand, N-(2-amino-5-bromopyridine-3-sulfonyl)-N-Me aminoacetic acid, available from I and sarcosine, undergoes intramol. cyclization on treatment with 1,1′-carbonyldiimidazole (CDI) at 40-100° to form novel pyrido[2,3-f][1,2,5]thiadiazepinone S,S-dioxide II. The reaction of N,N’-unsubstituted 2-amino-5-bromopyridine-3-sulfonamide with succinic anhydride afforded novel trioxocyclopenta[3,4]pyrido[2,3-e][1,2,4]thiadiazine III, which readily reacts with amines in the presence of CDI to provide the combinatorial library of pyrido[2,3-e][1,2,4]thiadiazines IV (R1R2NH is primary or secondary aliphatic cycloaliphatic, aromatic or heterocyclic amine). The mol. parameters, such as mol. weight, lipophilicity or a total number of hydrogen bond donors and acceptors, have been calculated for some of the products. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1COA of Formula: C7H16N2).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).COA of Formula: C7H16N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics