Kikumoto, Ryoji et al. published their research in Journal of Medicinal Chemistry in 1984 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Synthetic Route of C7H16N2

Substituted (ω-aminoalkoxy)stilbene derivatives as a new class of anticonvulsants was written by Kikumoto, Ryoji;Tobe, Akihiro;Fukami, Harukazu;Ninomiya, Kunihiro;Egawa, Mitsuo. And the article was included in Journal of Medicinal Chemistry in 1984.Synthetic Route of C7H16N2 This article mentions the following:

(ω-Aminoalkoxy)stilbenes I [R1 = H, Cl, F, 2-MeO, 2-Me, 3,4-Cl2; R2 = H, 3-MeO, 5-Cl; R3 = NMe2, NEt2, NHMe, NPr2, 1-pyrrolidinyl, 1-piperidinyl, morpholino, 4-alkyl-1-piperazinyl, 3-R4-substituted-1-piperidinyl (R4 = OH, alkoxy, OAc, CH2OH, CONH2, CO2Me, Me, CO2H); n = 2-5] and II (butoxy at 2, 3, 4) were prepared by successive Grignard reaction of benzyl chlorides III with salicylaldehydes IV, dehydration of (1-hydroxyphenethyl)phenols, ω-bromoalkylation of hydroxy-trans-stilbenes, and amination of the product bromoalkyl ethers with amines. The effect of structural modification of these mols. on the activities was examined Potent anticonvulsant activity was displayed by 2-[4-(4-methyl-1-piperazinyl)butoxy]stilbene and piperidinobutoxystilbene derivatives V (R4 = OH, OMe, OEt, and OAc) as determined by maximal electroshock seizure (MES) and pentylenetetrazol-induced convulsion tests in mice. V (R4 = OH) exhibited more potent anti-MES activity than diphenylhydantoin and carbamazepine in further pharmacol. tests in rats, and its therapeutic index was superior to those of two antiepileptic drugs. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Synthetic Route of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Synthetic Route of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics