Mustafa, Mohammad S. et al. published their research in Molecules in 2011 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Category: piperazines

Synthesis, and antitumor activity of some N1-(7-coumarinyl)amidrazones and related congeners was written by Mustafa, Mohammad S.;El-Abadelah, Mustafa M.;Zihlif, Malek A.;Naffa, Randa G.;Mubarak, Mohammad S.. And the article was included in Molecules in 2011.Category: piperazines This article mentions the following:

Piperazine coumarin amidrazone derivatives and related congeners were designed, the synthesis of the target compounds was achieved using 2-oxo-N-(2-oxo-4-methyl-2H-1-benzopyran-7-yl)propanehydrazonoyl chloride and piperazine derivatives, piperidine, morpholine, thiomorpholine, 1-[2-ethyl-4-nitro-1-(phenylmethyl)-1H-imidazol-5-yl]piperazine, etc., as reactants and the products thus obtained [i.e., 1-(1-piperazinyl)-1,2-propanedione 1-[2-(3-methyl-2-oxo-2H-1-benzopyran-7-yl)hydrazone] derivatives, amidrazones] were confirmed by elemental analyses, 1H-NMR, 13C-NMR, and ESI-HRMS spectral data. The title compounds were evaluated against the cell line MCF-7 (human mammary adenocarcinoma cell line), cell line K562 (human chronic myelogenous leukemia cell line), cell line HL60 (human promyelocytic leukemia cell line) and cell line ZR-75-1 (human mammary tumor, breast carcinoma cell line) it was discovered that they displayed activity as antitumor agents. Among all the compounds tested, 7-[2-[1-[4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)-1-piperazinyl]-2-(oxo)propylidene]hydrazinyl]-4-methyl-2-chromenone was the most potent against MCF-7 and K562 cells, with IC50 values of 20.2 and 9.3 μM, resp. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Category: piperazines).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics