Novel 4-substituted 2-piperazinylquinazolines as potent anticonvulsive and antihypoxic agents was written by Hori, Manabu;Iemura, Ryuichi;Hara, Hideaki;Ozaki, Akio;Sukamoto, Takayuki;Ohtaka, Hiroshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1990.Synthetic Route of C7H16N2 This article mentions the following:
Piperazinylquinazolines, e.g. I [R = Me, Ph, CH2Ph, CH2CH:CH2, (CH2)nMe, R1 = Me, CH2Ph, (CH2)nMe, n = 2-4] were prepared and examined for anticonvulsive and antihypoxic activities. The anal. of quant. structure-activity relationships indicated that the anticonvulsive activity was related to the lipophilicity of the compounds Most of the alkoxyquinazolines I showed potent anticonvulsive and antihypoxic activities. There is a good correlation between the potencies of these activities. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Synthetic Route of C7H16N2).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Synthetic Route of C7H16N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics