Synthesis of substituted 5-amino-3-aryl-4-(methoxycarbonyl)isoxazoles was written by Alyab’ev, S. B.;Kosul’nikova, T. S.;Dmitriev, D. E.;Il’in, A. P.;Kravchenko, D. V.;Filimonov, S. I.;Ivashchenko, A. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2007.Category: piperazines This article mentions the following:
A combinatorial library of substituted 5-amino-3-aryl-4-(methoxycarbonyl)isoxazoles was obtained by reaction of 3-aryl-4-methoxycarbonyl-5-chloroisoxazoles with primary and secondary amines in 1,4-dioxane in the presence of NEt3 under parallel synthesis conditions. Products were obtained in yields of 21-95%. This reaction proceeds less uniformly in DMF in the presence of K2CO3, and, in the case of primary amines, bis(4-methoxycarbonyl-3-aryl-isoxazol-5-yl)arylamines are also formed in 20-69% yields. In the experiment, the researchers used many compounds, for example, 4-(4-Ethylpiperazin-1-ylmethyl)phenylamine (cas: 611225-86-6Category: piperazines).
4-(4-Ethylpiperazin-1-ylmethyl)phenylamine (cas: 611225-86-6) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 鎺矯 and boils at 125閳?30 鎺矯. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics