Broad spectrum alkynyl inhibitors of T315I Bcr-Abl was written by Deng, Xianming;Lim, Sang Min;Zhang, Jianming;Gray, Nathanael S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Electric Literature of C14H20F3N3 This article mentions the following:
A series of alkyne-containing type II inhibitors with potent inhibitory activity of T315I Bcr-Abl has been identified. The most active compound 4 exhibits an EC50 of less than 1 nM against wild-type Bcr-Abl and an EC50 of 10 nM against T315I mutant but is broadly active against a number of other kinases. In the experiment, the researchers used many compounds, for example, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6Electric Literature of C14H20F3N3).
4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Electric Literature of C14H20F3N3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics