An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFR浼?and kit was written by Deng, Xianming;Zhou, Wenjun;Weisberg, Ellen;Wang, Jinhua;Zhang, Jianming;Sasaki, Takaaki;Nelson, Erik;Griffin, James D.;Janne, Pasi A.;Gray, Nathanael S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Product Details of 630125-91-6 This article mentions the following:
The synthesis and characterization of a number of 3-amino-1H-indazol-6-yl-benzamides that were designed to target the ‘DFG-out’ conformation of the kinase activation loop were reported. Several compounds such as I [R = H, Me] exhibit single-digit nanomolar EC50s against FLT3, c-Kit and the gatekeeper T674M mutant of PDGFR浼? In the experiment, the researchers used many compounds, for example, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6Product Details of 630125-91-6).
4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Product Details of 630125-91-6
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics