Novel water-soluble sedative-hypnotic agents: isoindolin-1-one derivatives was written by Kanamitsu, Norimasa;Osaki, Takashi;Itsuji, Yutaka;Yoshimura, Masakazu;Tsujimoto, Hisashi;Soga, Manabu. And the article was included in Chemical & Pharmaceutical Bulletin in 2007.Synthetic Route of C7H16N2 This article mentions the following:
The authors developed new i.v. sedative-hypnotic compounds with the isoindolin-1-one skeleton focusing on the water-soluble property and in vivo safety. The authors synthesized approx. 170 derivatives and evaluated their hypnotic effects by i.v. administration of the compounds to mice. A series of the 2-phenyl-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]isoindolin-1-one analogs (I–IV) showed potent sedative-hypnotic activity with good water solubility and a wide safety margin. The hypnotic doses (HD50s) of these 4 compounds when administered to mice were 2.35, 1.90, 2.17, and 3.12 mg/kg, resp., and the LDs (LD50s) were 88.67, 64.69, >120, and >120 mg/kg, resp. The therapeutic indexes (LD50/HD50) were 37.73, 34.05, >55.30, and >38.46, resp. Among these IV is being considered as the most potential candidate for clin. trials in humans. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Synthetic Route of C7H16N2).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 鎺矯 and boils at 125閳?30 鎺矯. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Synthetic Route of C7H16N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics