Molecular Simplification of 1,4-Diazabicyclo[4.3.0]nonan-9-ones Gives Piperazine Derivatives That Maintain High Nootropic Activity was written by Manetti, Dina;Ghelardini, Carla;Bartolini, Alessandro;Dei, Silvia;Galeotti, Nicoletta;Gualtieri, Fulvio;Romanelli, Maria Novella;Teodori, Elisabetta. And the article was included in Journal of Medicinal Chemistry in 2000.SDS of cas: 21867-64-1 This article mentions the following:
Several 4-substituted 1-acylpiperazines, obtained by mol. simplification of 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones, have been synthesized and tested in vivo on the mouse passive avoidance test, to evaluate their nootropic activity. The results show that, apparently, an N-acylpiperazine group can mimic the 2-pyrrolidinone ring of 1,4-diazabicyclo[4.3.0]nonan-9-one, as the compounds of the new series maintain high nootropic activity. Moreover mol. simplification produces more clear-cut structure-activity relationships with respect to the parent series. The mechanism of action also appears to be similar in the two series. In fact, although the mol. mechanism remains to be elucidated, the most potent compound of each class is able to increase acetylcholine release in rat brain. Piperazine derivatives represent a new class of nootropic drugs with an in vivo pharmacol. profile very similar to that of piracetam, showing much higher potency with respect to the reference compound Among the compounds studied, 1-benzoyl-4-propionylpiperazine (DM235) shows outstanding potency, being active at a dose of 0.001 mg kg-1 s.c. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1SDS of cas: 21867-64-1).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.SDS of cas: 21867-64-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics