New 1-aryl-3-substituted propanol derivatives as antimalarial agents was written by Perez-Silanes, Silvia;Berrade, Luis;Garcia-Sanchez, Rory N.;Mendoza, Adela;Galiano, Silvia;Perez-Solorzano, Berta Martin;Nogal-Ruiz, Juan J.;Martinez-Fernandez, Antonio R.;Aldana, Ignacio;Monge, Antonio. And the article was included in Molecules in 2009.Application In Synthesis of 1-Boc-4-(4-Nitrophenyl)piperazine This article mentions the following:
This paper describes the synthesis and in vitro antimalarial activity against a P. falciparum 3D7 strain of some new 1-aryl-3-substituted propanol derivatives Twelve of the tested compounds showed an IC50 lower than 1 娓璏. These compounds were also tested for cytotoxicity in murine J774 macrophages. The most active compounds were evaluated for in vivo activity against P. berghei in a 4-day suppressive test. Compound 12 inhibited more than 50% of parasite growth at a dose of 50 mg/kg/day. In addition, an FBIT test was performed to measure the ability to inhibit ferriprotoporphyrin biocrystn. This data indicates that 1-aryl-3-substituted propanol derivatives hold promise as a new therapeutic option for the treatment of malaria. In the experiment, the researchers used many compounds, for example, 1-Boc-4-(4-Nitrophenyl)piperazine (cas: 182618-86-6Application In Synthesis of 1-Boc-4-(4-Nitrophenyl)piperazine).
1-Boc-4-(4-Nitrophenyl)piperazine (cas: 182618-86-6) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Application In Synthesis of 1-Boc-4-(4-Nitrophenyl)piperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics