Improved synthesis of 4-[4-(5-oxo-1,5-dihydro-[1,2,4 triazoyl-4-yl) phenyl]piperazine-1-carboxylic t-butyl ester was written by Sheng, Chunquan;Zhang, Wannian;Xu, Hui;Che, Xiaoying;Zhang, Min;Yao, Jianzhong;Miao, Zhenyuan. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2006.Computed Properties of C15H21N3O4 This article mentions the following:
To improve the synthetic process of 4-[4-(5-oxo-1,5-dihydro-[1,2,4] triazoyl-4-yl) phenyl] piperazine-1-carboxylic t-Bu ester, which was used as the key intermediate of triazole antifungal agents, the product was synthesized from 1-(4-nitrophenyl) piperazine by Boc protection, reduction of nitro group, acylation, hydrazinolysis and cyclization. The new synthetic process had several advantages such as facile reaction condition, convenient operation and purification without chromatog. The overall yield was improved from 39.10% to 71.94%. In the experiment, the researchers used many compounds, for example, 1-Boc-4-(4-Nitrophenyl)piperazine (cas: 182618-86-6Computed Properties of C15H21N3O4).
1-Boc-4-(4-Nitrophenyl)piperazine (cas: 182618-86-6) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Computed Properties of C15H21N3O4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics