Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding was written by Wang, Gary T.;Wang, Sheldon;Gentles, Robert;Sowin, Thomas;Leitza, Sandra;Reilly, Edward B.;von Geldern, Thomas W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Synthetic Route of C7H16N2 This article mentions the following:
2-Amino-4-Ph pyridine and to a lesser extent, 4-amino-6-Ph pyrimidine were established as isosteres of trans-cinnamide moiety. Applying this isosterism to previously reported p-arylthio cinnamides resulted in the identification of 4-amino-6-(p-arylthio)phenylpyrimidines and 2-amino-4-(p-arylthio)phenylpyridines I (X = N, CH, R1 = 2-Me2CH; X = CH, R1 = 2-MeO, 3,4-OCH2CH2O; R2R3N = pyrrolidinyl, 4-hydroxypiperidinyl, 4-formyl-1-piperazinyl, etc.) as potent antagonists of LFA-1/ICAM-1 binding. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Synthetic Route of C7H16N2).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Synthetic Route of C7H16N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics