Chemotherapeutically active nitro compounds. 4. 5-Nitroimidazoles. Part II was written by Winkelmann, E.;Raether, W.;Sinharay, A.. And the article was included in Arzneimittel-Forschung in 1978.Application In Synthesis of 1-Propylpiperazine This article mentions the following:
About 190 nitroimidazoles I [R = morpholino, 4-methylpiperazino, N3, p-ClC6H4COCH2S, PhS, MeOCS2, H2NC(:NH)S, MeNH, etc.; R1 = Me, Et] were prepared Thus, I (R = Cl, R1 = Me) was treated with 2-mercaptopyridine to give 80% I (R = 2-pyridylthio, R1 = Me). 1-Methyl-2-(S-isothiouroniummethyl)-5-nitroimidazole-HCl and 2-bromo-5-nitrofuran gave 65% I (R = 5-nitro-2-furylthio, R1 = Me). The chemotherapeutic effect against several protozoa species was tabulated. Some I were also bactericidal, nematocidal, and fungicidal. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Application In Synthesis of 1-Propylpiperazine).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application In Synthesis of 1-Propylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics