Determination of some phenothiazine neuroleptics by means of absorption spectrophotometry was written by Basavaiah, K.;Krishnamurthy, G.;Swamy, J. Manjunatha. And the article was included in Eastern Pharmacist in 1998.Safety of N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide This article mentions the following:
A simple, rapid and sensitive spectrophotometric method was described for the quant. determination of 6 phenothiazine-based antipsychotic and anticholinergic drugs in bulk and in formulations. The method is based on the formation of stable phenothiazinium free radical cation by the use of sodium nitroprusside as the chromogenic agent. The drugs in a 1.5-2.5M H2SO4 medium reacted with the reagent to give intense orange or purple products which had characteristic absorption maxima at 500-530 nm. Beer’s law was obeyed over the concentration range 4-32 渭g/mL with apparent molar absorptivities ranging from 9.8 脳 103 16.59 脳 103 l.mol.-1 cm-1. The average percent recovery was 99.5-101.6. The accuracy and precision of the assay method were comparable to those of the British Pharmacopeia method. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Safety of N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide).
N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Safety of N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics