The relative bioavailability of paracetamol after rectal administration of suppositories containing a mixture of paracetamol, codeine phosphate and buclizine hydrochloride in healthy volunteers was written by Burgess, H. A.;Merrington, D. M.;Oliver, W. J.;Thomson, A.;Rogers, H. J.. And the article was included in Current Medical Research and Opinion in 1985.Reference of 129-74-8 This article mentions the following:
The bioavailability of paracetamol (I) [103-90-2] from suppositories containing I, codeine phosphate [52-28-8], and buclizine-HCl [129-74-8] was studied in healthy volunteers. No significant difference in bioavailability between suppositories stored 6 and 30 mo. was found. Mean peak plasma concentrations for 6 and 30 mo old suppositories were 4.75 mg/L and 4.6 mg/L, resp., mean elimination half-life was 4.4 h and 3.73 h, resp. and areas under the concentration-time curve were 2273 mg L-1 min and 2338 mg L-1 min, resp. These bioavailability data were similar to those obtained in a study where suppositories containing only I were used, indicating that the presence of codeine and buclizine in the suppository formulation did not affect the absorption of I. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Reference of 129-74-8).
1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Reference of 129-74-8
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics