Volume changes in the proton ionization of amines in water. 1. Morpholines and piperazines was written by Cabani, S.;Mollica, V.;Lepori, L.;Lobo, S. T.. And the article was included in Journal of Physical Chemistry in 1977.Application In Synthesis of Piperazine Dihydrochloride This article mentions the following:
Apparent molar volumes, 桅v, at various concentrations in water at 25掳 of some cyclic bifunctional amines [morpholine, 4-methylmorpholine, piperazine, 1-methyl- and 1,4-dimethylpiperazine, 1,4-diazabicyclo[2.2.2]octane (triethylenediamine)] and their mono- and dihydrochlorides were determined The volume changes 螖V1掳 and 螖V2掳, involved in the 1st and 2nd proton ionizations from the protonated amines, were calculated from the limiting partial molar volumes V虆2掳. The volumes of ionization for the bifunctional cyclic amines were compared with those for the monofunctional amines ad the relationship between entropies and volumes of ionization was examined In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Application In Synthesis of Piperazine Dihydrochloride).
Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application In Synthesis of Piperazine Dihydrochloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics