1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}ethanone was written by Dayananda, A. S.;Yathirajan, H. S.;Keeley, Amanda C.;Jasinski, Jerry P.. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2012.Electric Literature of C17H18F2N2 This article mentions the following:
In the title compound, C19H20F2N2O, the six-membered piperazine group adopts a slightly distorted chair conformation. The dihedral angle between the mean planes of the two benzene rings is 73.4(6)掳. The mean plane of the ethanone group is twisted from the mean planes of the two benzene rings by 66.7(8) and 86.2(6)掳. In the crystal, C-H路路路O and C-H路路路F interactions link the mols., forming a three-dimensional structure. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Electric Literature of C17H18F2N2).
4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Electric Literature of C17H18F2N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics