Impact of Heat Inactivation of Blood Samples on Therapeutic Drug Monitoring of 5 Second-Generation Antipsychotics and Their Metabolites was written by Ding, Jing;Yang, Liu;Zhang, Yan;Zhang, Suo;Meng, Zhuocheng. And the article was included in Therapeutic Drug Monitoring in 2022.COA of Formula: C23H25Cl2N3O2 This article mentions the following:
The severe acute respiratory syndrome coronavirus 2 outbreak has been classified as a pandemic. Because many coronaviruses are heat sensitive, heat inactivation of patient samples at 56掳C before testing reduces the risk of transmission. The aim of this study is to assess the impact of heat inactivation of patient blood samples on plasma concentrations of 5 second-generation antipsychotics and their metabolites. Blood samples were collected during routine clin. therapeutic drug monitoring examination between Apr. 3, 2021, and Apr. 19, 2021. Samples were divided into 2 groups: group A, noninactivated raw sample, and group B, inactivated samples. Inactivation was performed by a 30-min incubation at 56掳C. The levels of the 5 drugs and their metabolites before and after sample heat inactivation were measured using liquid chromatog.-tandem mass spectrometry and compared. Furthermore, correlation and Bland-Altman analyses were conducted. No statistically significant difference was observed between the levels of the 5 drugs and their metabolites (ie, risperidone, 9-OH-risperidone, aripiprazole, dehydroaripiprazole, olanzapine, quetiapine, norquetiapine, clozapine, and norclozapine) in the noninactivated group A and the inactivated group B (P 掳 0.05). Each drug鈥瞫 concentration values in inactivated and noninactivated treatments correlated (Spearman rs 掳 0.98; P 0.001). The results of the noninactivated treatment methods and samples alone showed good consistency via Bland-Altman anal. Blood sample heat inactivation had no significant effect on the therapeutic drug monitoring of 5 second-generation antipsychotics and their metabolites. This inactivated treatment method should be recommended to effectively protect laboratory staff from virus contamination. In the experiment, the researchers used many compounds, for example, 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (cas: 129722-25-4COA of Formula: C23H25Cl2N3O2).
7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (cas: 129722-25-4) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.COA of Formula: C23H25Cl2N3O2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics