Design, Synthesis, and Antibacterial Evaluation of Propylene-tethered 8-Methoxyl Ciprofloxacin-isatin Hybrids was written by Guo, Hua. And the article was included in Journal of Heterocyclic Chemistry in 2018.Application of 112811-57-1 This article mentions the following:
A series of 8-methoxyl ciprofloxacin (8-OMe CPFX)-isatin hybrids tethered through propylene were designed, synthesized, and examined for their in vitro antibacterial activities against a panel of Gram-pos. and Gram-neg. pathogens including drug-resistant bacteria. All the synthesized hybrids (min. inhibitory concentration: ≤0.03-64 μg/mL) exhibited considerable activities against the tested strains, especially against the Gram-neg. pathogens. Among them, hybrid 11-Cyclopropyl-6-fluoro-8-methoxy-7-(4-(3-(5-methyl-2,3-dioxoindolin-1-yl)propyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid was no inferior to the parent 8-OMe CPFX that could act as a starting point for further optimization. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 112811-57-1Application of 112811-57-1).
1-Cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 112811-57-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Application of 112811-57-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics