Characteristics of drugs evaluated by computational chemistry. (5). Typical antipsychotics was written by Hayano, Taizo;Kishioka, Shiroh;Yamamoto, Hiroyuki;Ikoma, Yoshihisa. And the article was included in Wakayama Igaku in 2005.Synthetic Route of C22H30N4O2S2 This article mentions the following:
Antipsychotics are divided into two types, i.e. typical type and atypical type. Typical type mainly includes phenothiazines and butyrophenones. Risperidone is located on the boundary. We furthermore divide the typical type into umbrella shape and cylindrical shape based on the mol. form. They have the side chain that connect with main ring with characteristic bond angle. Electron d. was high on main ring where HOMO and LUMO localized and low on terminal chain. Statistical anal. showed that there are no significant difference on the electron energies, the dipole moments, the dihedral angles between umbrella shape mols. and cylindrical ones. These results suggested the importance of the Pr group joining to the side chain with main ring. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Synthetic Route of C22H30N4O2S2).
N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Synthetic Route of C22H30N4O2S2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics